TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.

Product information

CAS Number: 339071-18-0

Molecular Weight: 255.70

Formula: C11H14ClN3O2

Chemical Name: N'-[3-chloro-4-(morpholin-4-yl)phenyl]-N-hydroxymethanimidamide

Smiles: ONC=NC1=CC(Cl)=C(C=C1)N1CCOCC1

InChiKey: ZTXADXBIGLLOFX-UHFFFAOYSA-N

InChi: InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (977.71 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05). In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%.

Products are for research use only. Not for human use.