Will this work as a direct replacement for factory rubber hose?

It's the same diameter, so routing-wise yes — but verify your factory hose length and clamp style first. Straight sections don't account for bends, so you may need to order a different configuration or combine multiple sections.

Do I need clamps, and what size?

You'll need hose clamps to secure the ends to barbed fittings. Standard stainless steel clamps work fine — your current system's clamp size tells you what to grab. They're not included here.

Can I use this on a boosted or turbo setup?

Silicone handles boost pressure well — the 3-ply reinforcement is built for it. Just match the hose diameter to your turbo intake specs and use quality clamps rated for boost pressure.